What Peptides Are Best for Weight Loss? - and Why?

Losing weight isn’t just about diet and exercise anymore — it’s about optimizing your body’s natural biology. Peptides offer a safe, science-backed way to support fat loss, improve energy, and rebalance metabolism.

At ZenVia, we’ve curated a collection of Weight Loss & Metabolism Peptides that work with your body — not against it — to help you achieve sustainable, long-term results.

How Peptides Support Weight Loss

Peptides act as metabolic messengers, signaling your body to increase fat oxidation, reduce appetite, and improve insulin sensitivity.

Here’s how they make a difference:

• Regulate hunger hormones like GLP-1 and GIP to reduce cravings.

• Enhance fat metabolism by targeting stored lipids and boosting energy.

• Promote lean muscle growth to naturally raise your metabolism.

• Support mitochondrial health — your body’s energy engines.

By improving these internal systems, peptides help you burn fat more efficiently and maintain results without extreme diets or burnout.

ZenVia’s Top Peptides for Weight Loss

Semaglutide: A leading GLP-1 receptor agonist that reduces appetite, improves blood sugar control, and supports gradual, sustainable fat loss.

Why it works: It slows gastric emptying, helping you feel fuller for longer while stabilizing energy levels.

Tirzepatide: Dual GLP-1/GIP agonist known for even greater results in both fat reduction and metabolic health.

Why it works: It influences multiple hormonal pathways to reduce cravings and improve glucose metabolism.

Retatrutide: A next-generation triple agonist targeting GLP-1, GIP, and glucagon receptors — designed for potent, full-body metabolic benefits.

Why it works: It helps your body burn more fat while maintaining lean muscle and stable energy.

Tesamorelin: A growth hormone–releasing peptide that targets visceral fat (especially in the abdominal area).

Why it works: It stimulates the release of natural growth hormone, improving muscle tone and metabolic balance.

AOD-9604: Often called the “fat-burning fragment,” this peptide enhances lipid metabolism without affecting blood sugar or growth hormone levels.

Why it works: It encourages fat breakdown and prevents new fat cell formation.

5-Amino-1MQ: Supports fat metabolism at the cellular level by improving NAD+ availability and mitochondrial efficiency.

Why it works: It activates key enzymes involved in fat oxidation and energy production.

Cagrilintide: An amylin analog that complements GLP-1 peptides by boosting satiety and stabilizing appetite.

Why it works: Works synergistically with Semaglutide or Tirzepatide to reduce hunger and maintain long-term weight loss.

MOTS-C (Motilin):

A mitochondrial peptide that enhances energy production and improves metabolic resilience.

Why it works: It helps the body adapt to stress and enhances cellular fat utilization.

Stacking Peptides for Fat Loss

Many ZenVia clients find optimal results by stacking peptides that target different mechanisms.

Example combinations include:

• Semaglutide + 5-Amino-1MQ for appetite and metabolism synergy.

• Tesamorelin + AOD-9604 for fat reduction and body composition improvement.

• Tirzepatide + Cagrilintide for maximum hormonal balance and fat control.

Learn more about how stacking works in our Peptide Stack Guide.

Tips for Best Results

• Maintain a balanced, high-protein diet to preserve muscle.

• Stay hydrated — peptides work best when your cells are well-nourished.

• Prioritize sleep and recovery, as these directly affect metabolism.

• Be consistent — peptide results build gradually over time.

Explore ZenVia’s Weight Loss Peptide Collection

If you’re ready to achieve real, lasting results, ZenVia’s curated peptide selection can help you take control of your metabolism naturally.

Browse our Weight Loss & Metabolism Peptides and find the right combination for your goals.